4,655 research outputs found
Recommended from our members
Statin Inhibition of Fc Receptor–Mediated Phagocytosis by Macrophages Is Modulated by Cell Activation and Cholesterol
Objectives— An inflammatory response to altered lipoproteins that accumulate in the arterial wall is a major component of the pathogenesis of atherosclerosis. Statins reduce plasma levels of low-density lipoprotein (LDL) and are effective treatments for atherosclerosis. It is hypothesized that they also modulate inflammation. The aim of this study was to examine whether lovastatin inhibits macrophage inflammatory processes and clarify its mechanism of action.
Methods and Results— We examined the effects of statins on phagocytosis of antibody-coated red blood cells by cultured human monocytes and mouse peritoneal macrophages. Lovastatin, simvastatin, and zaragozic acid, a squalene synthase inhibitor, blocked Fc receptor–mediated phagocytosis by cultured human monocytes and mouse peritoneal macrophages. The inhibitory effect of lovastatin on Fc receptor–mediated phagocytosis was prevented completely by addition of mevalonate, farnesyl pyrophosphate, LDL, or cholesterol to the culture medium. The inhibitory effect of zaragozic acid was reversed by addition of LDL, but not by the addition of geranylgeranyl pyrophosphate, to the medium. In addition, the effect of lovastatin on phagocytosis is a function of cell activation because treatment of cells with tumor necrosis factor-α or lipopolysaccharide prevented inhibition of phagocytosis by lovastatin.
Conclusions— The inhibition of Fc receptor–mediated phagocytosis of lovastatin is related to its effect on cholesterol biosynthesis rather than its effect on the formation of isoprenoids
The dependence of oxygen and nitrogen abundances on stellar mass from the CALIFA survey
We analysed the optical spectra of HII regions extracted from a sample of 350
galaxies of the CALIFA survey. We calculated total O/H abundances and, for the
first time, N/O ratios using the semi-empirical routine HII-CHI-mistry, which,
according to P\'erez-Montero (2014), is consistent with the direct method and
reduces the uncertainty in the O/H derivation using [NII] lines owing to the
dispersion in the O/H-N/O relation. Then we performed linear fittings to the
abundances as a function of the de-projected galactocentric distances. The
analysis of the radial distribution both for O/H and N/O in the non-interacting
galaxies reveals that both average slopes are negative, but a non-negligible
fraction of objects have a flat or even a positive gradient (at least 10\% for
O/H and 4\% for N/O). The slopes normalised to the effective radius appear to
have a slight dependence on the total stellar mass and the morphological type,
as late low-mass objects tend to have flatter slopes. No clear relation is
found, however, to explain the presence of inverted gradients in this sample,
and there is no dependence between the average slopes and the presence of a
bar. The relation between the resulting O/H and N/O linear fittings at the
effective radius is much tighter (correlation coefficient = 0.80) than
between O/H and N/O slopes ( = 0.39) or for O/H and N/O in the
individual \hii\ regions ( = 0.37). These O/H and N/O values at the
effective radius also correlate very tightly (less than 0.03 dex of dispersion)
with total luminosity and stellar mass. The relation with other integrated
properties, such as star formation rate, colour, or morphology, can be
understood only in light of the found relation with mass.Comment: Accepted for publication in A&A. 20 pages, 19 figure
Patient satisfaction with anaesthesia care: development of a psychometric questionnaire and benchmarking among six hospitals in Switzerland and Austria†‡
Background. We describe the development and comparison of a psychometric questionnaire on patient satisfaction with anaesthesia care among six hospitals. Methods. We used a rigorous protocol: generation of items, construction of the pilot questionnaire, pilot study, statistical analysis (construct validity, factor analysis, reliability analysis), compilation of the final questionnaire, main study, repeated analysis of construct validity and reliability. We compared the mean total problem score and the scores for the dimensions: ‘Information/Involvement in decision‐making', and ‘Continuity of personal care by anaesthetist'. The influence of potential confounding variables was tested (multiple linear regression). Results. The average problem score from all hospitals was 18.6%. Most problems are mentioned in the dimensions ‘Information/Involvement in decision‐making' (mean problem score: 30.9%) and ‘Continuity of personal care by anaesthetist' (mean problem score: 32.2%). The overall assessment of the quality of anaesthesia care was good to excellent in 98.7% of cases. The most important dimension was ‘Information/Involvement in decision‐making'. The mean total problem score was significantly lower for two hospitals than the total mean for all hospitals (significantly higher at two hospitals) (P<0.05). Amongst the confounding variables considered, age, sex, subjective state of health, type of anaesthesia and level of education had an influence on the total problem score and the two dimensions mentioned. There were only marginal differences with and without the influence of the confounding variables for the different hospitals. Conclusions. A psychometric questionnaire on patient satisfaction with anaesthesia care must cover areas such as patient information, involvement in decision‐making, and contact with the anaesthetist. The assessment using summed scores for dimensions is more informative than a global summed rating. There were significant differences between hospitals. Moreover, the high problem scores indicate a great potential for improvement at all hospitals. Br J Anaesth 2002; 89: 863-7
On the theory of tumor self-seeding: implications for metastasis progression in humans
Metastasis remains the leading cause of death among cancer patients because few effective treatment options are available. A recent paper proposes a new twist on metastasis. The paper shows that circulating tumor cells can return to the primary tumor, a process termed tumor self-seeding or cross-seeding, and that this helps breeding tumor cells that give rise to aggressive metastatic variants. A viewpoint presented here addresses the implications of these studies for human cancer metastasis
A search for resonant production of pairs in $4.8\ \rm{fb}^{-1}p\bar{p}\sqrt{s}=1.96\ \rm{TeV}$
We search for resonant production of tt pairs in 4.8 fb^{-1} integrated
luminosity of ppbar collision data at sqrt{s}=1.96 TeV in the lepton+jets decay
channel, where one top quark decays leptonically and the other hadronically. A
matrix element reconstruction technique is used; for each event a probability
density function (pdf) of the ttbar candidate invariant mass is sampled. These
pdfs are used to construct a likelihood function, whereby the cross section for
resonant ttbar production is estimated, given a hypothetical resonance mass and
width. The data indicate no evidence of resonant production of ttbar pairs. A
benchmark model of leptophobic Z \rightarrow ttbar is excluded with m_{Z'} <
900 GeV at 95% confidence level.Comment: accepted for publication in Physical Review D Sep 21, 201
Combined search for the standard model Higgs boson decaying to a bb pair using the full CDF data set
We combine the results of searches for the standard model Higgs boson based
on the full CDF Run II data set obtained from sqrt(s) = 1.96 TeV p-pbar
collisions at the Fermilab Tevatron corresponding to an integrated luminosity
of 9.45/fb. The searches are conducted for Higgs bosons that are produced in
association with a W or Z boson, have masses in the range 90-150 GeV/c^2, and
decay into bb pairs. An excess of data is present that is inconsistent with the
background prediction at the level of 2.5 standard deviations (the most
significant local excess is 2.7 standard deviations).Comment: To be published in Phys. Rev. Lett (v2 contains minor updates based
on comments from PRL
Measurement of the Cross Section and Triple Gauge Couplings in Collisions at TeV
This Letter describes the current most precise measurement of the
production cross section as well as limits on anomalous couplings at a
center-of-mass energy of 1.96 TeV in proton-antiproton collisions for the
Collider Detector at Fermilab (CDF). candidates are reconstructed from
decays containing three charged leptons and missing energy from a neutrino,
where the charged leptons are either electrons or muons. Using data collected
by the CDF II detector (7.1 fb of integrated luminosity), 63 candidate
events are observed with the expected background contributing events.
The measured total cross section pb is in good
agreement with the standard model prediction of . The same sample
is used to set limits on anomalous couplings.Comment: Resubmission to PRD-RC after acceptance (27 July 2012
The CALIFA and HIPASS Circular Velocity Function for All Morphological Galaxy Types
The velocity function (VF) is a fundamental observable statistic of the galaxy population that is similar to the luminosity function in importance, but much more difficult to measure. In this work we present the first directly measured circular VF that is representative between 60 < ν_(circ) < 320 km s^(−1) for galaxies of all morphological types at a given rotation velocity. For the low-mass galaxy population (60 < ν_(circ) < 170 km s^(−1), we use the HI Parkes All Sky Survey VF. For the massive galaxy population (170 < ν_(circ) < 320 km s^(−1), we use stellar circular velocities from the Calar Alto Legacy Integral Field Area Survey (CALIFA). In earlier work we obtained the measurements of circular velocity at the 80% light radius for 226 galaxies and demonstrated that the CALIFA sample can produce volume-corrected galaxy distribution functions. The CALIFA VF includes homogeneous velocity measurements of both late and early-type rotation-supported galaxies and has the crucial advantage of not missing gas-poor massive ellipticals that HI surveys are blind to. We show that both VFs can be combined in a seamless manner, as their ranges of validity overlap. The resulting observed VF is compared to VFs derived from cosmological simulations of the z = 0 galaxy population. We find that dark-matter-only simulations show a strong mismatch with the observed VF. Hydrodynamic simulations fare better, but still do not fully reproduce observations
Measurement of branching ratio and Bs0 lifetime in the decay Bs0 -> J/psi f0(980) at CDF
We present a study of Bs0 decays to the CP-odd final state J/psi f0(980) with
J/psi -> mu+ mu- and f0(980) -> pi+ pi-. Using ppbar collision data with an
integrated luminosity of 3.8/fb collected by the CDF II detector at the
Tevatron we measure a Bs0 lifetime of tau(Bs0 -> J/psi f0(980)) = 1.70
-0.11+0.12(stat) +-0.03(syst) ps. This is the first measurement of the Bs0
lifetime in a decay to a CP eigenstate and corresponds in the standard model to
the lifetime of the heavy Bs0 eigenstate. We also measure the product of
branching fractions of Bs0 -> J/psi f0(980) and f0(980) -> pi+ pi- relative to
the product of branching fractions of Bs0 -> J/psi phi and phi -> K+ K- to be
R_f0/phi = 0.257 +_0.020(stat) +-0.014(syst), which is the most precise
determination of this quantity to date.Comment: accepted by Phys. Rev.
- …